The heat wave poses a major to extreme heat risk for residents in the central and southern Plains, Mississippi Valley, and Southeast. Prolonged exposure to such conditions can lead to heat-related illnesses, including heat exhaustion and heat stroke. Vulnerable populations, such as the elderly, children, and those with pre-existing health conditions, are at heightened risk. The combination of high temperatures and humidity increases the likelihood of heat indices exceeding dangerous thresholds, making outdoor activities hazardous.