The primary risks associated with Hurricane Isaias include damaging winds, heavy rainfall, and life-threatening storm surges along the Gulf Coast. Areas under hurricane and tropical storm warnings, including parts of Alabama, Florida, Mississippi, and Louisiana, are at the highest risk. Coastal flooding and power outages are likely in affected regions. Residents in low-lying areas should be particularly cautious, as storm surges could lead to significant flooding. The NHC advises all individuals in the warning zones to take immediate precautions to protect life and property.