The Gulf Coast is bracing for significant impacts from Isaias, including flooding rains, damaging winds, and life-threatening storm surges. Coastal areas could see surges of 5 to 7 feet, particularly in Mississippi, Alabama, and the Florida Panhandle. Rainfall totals are expected to range from 3 to 6 inches, with isolated areas receiving up to 10 inches. Tornadoes are also possible as the storm moves inland. Residents in the affected areas should prepare for potential power outages, property damage, and hazardous travel conditions.