The rise in Vibrio infections poses a serious health risk to residents and visitors engaging in water activities or consuming raw shellfish from the Chesapeake Bay. Vulnerable populations, such as those with immune deficiencies or open wounds, are at higher risk of severe complications, including sepsis and death. The economic impact is also significant, with healthcare costs and lost income from Vibrio-related illnesses estimated at $238 million annually. Additionally, the oyster farming industry faces challenges in maintaining consumer trust and adhering to safety regulations.