The intensification of compound flood events poses significant risks to coastal communities, infrastructure, and economies. By late this century, portions of the U.S. Gulf and Atlantic coasts may become uninhabitable, even under moderate global warming scenarios. The increased frequency of extreme flooding could lead to tens of billions of dollars in damages annually. Vulnerable areas include major cities like Houston, Miami, and New York, where sea level rise and storm surges are expected to exacerbate flooding. Additionally, inland regions near rivers draining into the Gulf of Mexico are also at risk due to increased streamflow and rainfall. The growing threat could trigger mass migrations and strain emergency response systems.