Individuals taking medications that affect temperature regulation or sweating are at a higher risk of heat-related illnesses, such as heat exhaustion or heatstroke, during extreme heat events. This includes those on certain allergy medications, antidepressants, and antipsychotics. Symptoms to watch for include excessive sweating or an inability to sweat, which can signal the body's struggle to cool itself. Vulnerable populations, such as the elderly and those with pre-existing health conditions, may face heightened risks.