The road closures and weather-related disruptions are expected to impact commuters, weekend travelers, and residents in Phoenix and surrounding areas. Flash flooding poses a significant risk in low-lying areas and wash crossings, while dust storms can lead to hazardous driving conditions. Construction on major freeways like the I-10 and I-17 may cause detours and delays, particularly during weekends. Drivers are urged to exercise caution and plan alternative routes to avoid affected areas.