The San Joaquin Valley's agricultural workers, outdoor laborers, and residents engaging in outdoor activities are at heightened risk of contracting Valley Fever. Vulnerable groups include individuals over 60, those with weakened immune systems, and people of Hispanic or Latino origin, who have historically accounted for nearly half of the state's cases. Pets and livestock are also susceptible to the disease. While most cases result in mild respiratory symptoms, severe infections can lead to long-term health complications, including meningitis, which may require lifelong treatment. The disease is often underdiagnosed, with actual case numbers potentially 10 to 18 times higher than reported.