The rise in antibiotic-resistant Salmonella poses a significant public health risk, as it complicates the treatment of infections that already affect tens of millions of people annually. The study underscores that climate change is amplifying the spread of antimicrobial resistance, particularly in vulnerable regions with limited healthcare infrastructure. Extreme weather events, such as flooding and drought, further exacerbate the issue by spreading resistant bacteria through water systems or concentrating antibiotic residues in compromised water sources. Without intervention, the abundance of ARGs in Salmonella is projected to continue rising, potentially undermining the effectiveness of current antimicrobial therapies and increasing the global burden of hard-to-treat infections.