The impacts of a Super El Niño could be widespread, affecting millions of people across the United States and globally. Communities lacking adequate infrastructure and climate resilience are particularly vulnerable to extreme heat, flooding, and other weather-related hazards. Rising ocean and atmospheric temperatures are expected to amplify the severity of these events, with projections indicating a significant increase in temperature-related fatalities if global temperatures rise by 3°C above preindustrial levels. Urban areas, such as Washington, D.C., are implementing cooling initiatives and climate resilience plans, but much of this work remains incomplete. Without sufficient preparedness, the U.S. risks facing severe humanitarian and environmental consequences.