Muskoxen in the Canadian Arctic are facing a critical juncture due to the combined impacts of emerging diseases and climate change. Since 2009, a novel strain of *Erysipelothrix rhusiopathiae*, referred to as the 'Arctic clone,' has been responsible for widespread muskox deaths on Victoria and Banks islands. Compounding this issue is the growing prevalence of brucellosis, a zoonotic disease, which further endangers muskoxen on Victoria Island and mainland areas. These health threats are being monitored through a collaborative program involving Inuit hunters, scientists, and government bodies.