The increased rodent activity due to above-normal precipitation poses a heightened risk of hantavirus exposure, particularly in rural areas, mountain communities, and seasonal homes. While hantavirus infections are rare, they can lead to severe respiratory illness. The CDC has reported 890 laboratory-confirmed cases in the U.S. since 1993. The risk is particularly relevant during spring cleaning when people may encounter contaminated spaces. The ongoing outbreak aboard the MV Hondius cruise ship, involving Andes virus, underscores the importance of vigilance, though person-to-person transmission remains rare.