Alabama is preparing for significant impacts from Isaias, including coastal storm surges of 5 to 7 feet, heavy rainfall of 2 to 6 inches (with localized higher amounts), and strong winds. Inland areas south of I-20 could see gusts of 35-60 mph, with higher gusts near the storm's center. Flooding is likely in southern sections, and tornadoes are possible across the state. Residents should prepare for power outages and hazardous travel conditions.