The report identifies significant risks to human life, particularly in the Global South, where infrastructure and healthcare systems may struggle to cope with extreme heat. Nigeria is projected to experience the highest number of heat-related deaths, with 31,400 fatalities. Other heavily impacted countries include Indonesia, Sudan, India, and Brazil. In the United States, 3,500 deaths are anticipated. Beyond heat-related fatalities, El Niño is expected to exacerbate other extreme weather events such as fires, floods, and droughts, further straining resources and endangering lives. The study serves as a stark reminder of the compounded effects of natural climate patterns and human-induced global warming.