Travelers should prepare for potential disruptions due to varying weather conditions across the U.S. Snowfall in the Northeast, northern Appalachians, and Upper Midwest could lead to hazardous road conditions, while rain in the Atlantic Corridor and Lower Lakes region may cause delays. The Pacific Northwest may face heavy rainfall, increasing the risk of localized flooding. In contrast, the High Plains, Desert Southwest, and parts of California are expected to have favorable travel conditions with sunny weather. Those in the Southeast and Deep South should be prepared for temperature drops and possible rain. Travelers are advised to monitor local forecasts closely, especially for return trips after Thanksgiving, as weather conditions may change rapidly.